Pettit 2020.

Study characteristics
Notes	English title Obesity is associated with increased risk for mortality among hospitalized patients with COVID‐19 Study setting Start of study recruitment (MM/YYYY): 03/2020 End of study recruitment (MM/YYYY): 04/2020 Study design: Retrospective cohort Study centre(s): Single centre/clinic/area within a country Number of centres, clinics or areas: 1 Study setting: Inpatient Number of participants recruited: 238 Sampling method: Consecutive participants Participants Female participants (absolute number): 125 Age measure, value: Mean (SD), 58.5 (17) Inclusion criteria: All severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) positive patients admitted to the University of Chicago Medical Center, an 811‐bed academic medical centre on the south side of Chicago, between March 1, 2020, and April 18, 2020, who had completed their hospital course (including deceased patients) were included in the analysis. Exclusion criteria: NR Smoking frequency: NR Diabetes frequency: 68 Hypertension frequency: 126 Cardiovascular disease frequency: 51 Asthma frequency: 63 Chronic obstructive pulmonary disease frequency: NR Other pulmonary disease frequency: NR Immunosuppression frequency: 5 Chronic kidney disease frequency: 17 Cancer frequency: 27 Steroid administration frequency: NR Supplemental oxygen administration frequency: NR Other treatments (frequency): NR Prognostic factor(s) Study’s definition for obesity: BMI was analysed as a categorical variable with values of BMI < 25 (normal weight), 25 to < 30 (overweight), 30 to < 35 (obesity, class 1), 35 to < 40 (obesity, class 2), or ≥ 40 (obesity, class 3) The time when obesity has been measured: Before disease or right at presentation Main variable used for determination of obesity: BMI Threshold used for definition: 30 Obesity frequency (absolute number): 146 Prognostic factor(s): BMI > 30 kg/m2 Outcome(s) Mortality Outcome (prognostic factor) Mortality (BMI > 30 kg/m2) Follow‐up Number of patients followed completely for the outcome: 238 Number of obese patients followed completely for the outcome: 146 Number of non‐obese patients followed completely for the outcome: 92 Univariable unadjusted analysis for obesity Effect measure for obesity: Odds ratio Effect measure value (95% CI), P value: 1 (0.8, 1.4), 0.9 Multivariable analysis for obesity Modelling method: Logistic regression The set of prognostic factors used for adjustment: Age, CAD, cancer, CKD, DM, HF, HTN, hyperlipidaemia, sex, smoking, stroke, pulmonary disease, VTE Effect measure for obesity: Odds ratio Effect measure value (95% CI), P value: 1.7 (1.1, 2.8), 0.016
Item	Authors' judgement	Support for judgement
Study Participation	Yes	Appendix 3
Study Attrition Mortality	Yes	Appendix 3
Prognostic Factor Measurement	Yes	Appendix 3
Outcome Measurement Mortality	Yes	Appendix 3
Confounding Bias Mortality	Unclear	Appendix 3
Statistical Analysis Bias	Unclear	Appendix 3