Simonnet 2020.

Study characteristics
Notes	English title High prevalence of obesity in severe acute respiratory syndrome coronavirus‐2 (SARS‐CoV‐2) requiring invasive mechanical ventilation Study setting Start of study recruitment (MM/YYYY): 02/2020 End of study recruitment (MM/YYYY): 04/2020 Study design: Retrospective cohort Study centre(s): Single centre/clinic/area within a country Number of centres, clinics or areas: 1 Study setting: Inpatient Number of participants recruited: 124 Sampling method: Consecutive participants Participants Female participants (absolute number): 34 Age measure, value: Median (IQR), 60 (51‐70) Inclusion criteria: All patients admitted to intensive care for SARS‐CoV‐2 in Roger Salengro Hospital at Centre Hospitalier Universitaire de Lille (CHU Lille, France) between February 27, 2020, and April 5, 2020; SARS symptoms characterised by dyspnoea, increased respiratory frequency, decreased blood oxygen saturation, need for oxygen support therapy for at least 6L/min, throat swab PCR test positive Exclusion criteria: NR Smoking frequency: NR Diabetes frequency: 28 Hypertension frequency: 60 Cardiovascular disease frequency: NR Asthma frequency: NR Chronic obstructive pulmonary disease frequency: NR Other pulmonary disease frequency: NR Immunosuppression frequency: NR Chronic kidney disease frequency: NR Cancer frequency: NR Steroid administration frequency: NR Supplemental oxygen administration frequency: NR Other treatments (frequency): NR Prognostic factor(s) Study’s definition for obesity: Lean (BMI from 18.5 to < 25 kg/m2), overweight (BMI from 25 to < 30 kg/m2), moderate obesity (BMI from 30 to < 35 kg/m2), and severe obesity (BMI ≥ 35 kg/m2) The time when obesity has been measured: NR Main variable used for determination of obesity: BMI Threshold used for definition: 30 Obesity frequency (absolute number): 59 Prognostic factor(s):  Overweight (BMI from 25 to < 30 kg/m2) Moderate obesity (BMI from 30 to < 35 kg/m2) Severe obesity (BMI ≥ 35 kg/m2) Outcome(s) Mechanical ventilation Outcome (prognostic factor) Mechanical ventilation (overweight (BMI from 25 to < 30 kg/m2)) Follow‐up Number of patients followed completely for the outcome: 124 Number of obese patients followed completely for the outcome: 59 Number of non‐obese patients followed completely for the outcome: 65 Univariable unadjusted analysis for obesity Effect measure for obesity: Odds ratio Effect measure value (95% CI), P value: 1.72 (0.56, 5.23), 0.22 Multivariable analysis for obesity Modelling method: Logistic regression The set of prognostic factors used for adjustment: Age, DM, dyslipidaemia, HTN, sex Effect measure for obesity: Odds ratio Effect measure value (95% CI), P value: 1.69 (0.52, 5.48), 0.22 Outcome (prognostic factor) Mechanical ventilation (moderate obesity (BMI from 30 to < 35 kg/m2)) Follow‐up Number of patients followed completely for the outcome: 124 Number of obese patients followed completely for the outcome: 59 Number of non‐obese patients followed completely for the outcome: 65 Univariable unadjusted analysis for obesity Effect measure for obesity: Odds ratio Effect measure value (95% CI), P value: 3.38 (0.9, 12.72), 0.45 Multivariable analysis for obesity Modelling method: Logistic regression The set of prognostic factors used for adjustment: Age, DM, dyslipidaemia, HTN, sex Effect measure for obesity: Odds ratio Effect measure value (95% CI), P value: 3.45 (0.83, 14.31), 0.48 Outcome (prognostic factor) Mechanical ventilation (severe obesity (BMI ≥ 35 kg/m2)) Follow‐up Number of patients followed completely for the outcome: 124 Number of obese patients followed completely for the outcome: 59 Number of non‐obese patients followed completely for the outcome: 65 Univariable unadjusted analysis for obesity Effect measure for obesity: Odds ratio Effect measure value (95% CI), P value: 6.75 (1.76, 25.85), 0.015 Multivariable analysis for obesity Modelling method: Logistic regression The set of prognostic factors used for adjustment: Age, DM, dyslipidaemia, HTN, sex Effect measure for obesity: Odds ratio Effect measure value (95% CI), P value: 7.36 (1.63, 33.14), 0.021
Item	Authors' judgement	Support for judgement
Study Participation	Yes	Appendix 3
Study Attrition Mechanical ventilation	Unclear	Appendix 3
Prognostic Factor Measurement	Yes	Appendix 3
Outcome Measurement Mechanical ventilation	Yes	Appendix 3
Confounding Bias Mechanical ventilation	Yes	Appendix 3
Statistical Analysis Bias	Yes	Appendix 3