Sterling 2020.

Study characteristics
Notes	English title The Fibrosis‐4 Index is associated with need for mechanical ventilation and 30‐day mortality in patients admitted with coronavirus disease 2019 Study setting Start of study recruitment (MM/YYYY): 02/2020 End of study recruitment (MM/YYYY): 05/2020 Study design: Retrospective cohort Study centre(s): Single centre/clinic/area within a country Number of centres, clinics or areas: 1 Study setting: Inpatient Number of participants recruited: 256 Sampling method: Consecutive participants Participants Female participants (absolute number): 115 Age measure, value: Mean (SD), 58.5 (17.66) Inclusion criteria: Confirmed COVID‐19 by polymerase chain reaction (PCR) Exclusion criteria: NR Smoking frequency: NR Diabetes frequency: 47% Hypertension frequency: NR Cardiovascular disease frequency: 28 Asthma frequency: NR Chronic obstructive pulmonary disease frequency: NR Other pulmonary disease frequency: 24% Immunosuppression frequency: NR Chronic kidney disease frequency: NR Cancer frequency: NR Steroid administration frequency: NR Supplemental oxygen administration frequency: NR Other treatments (frequency): NR Prognostic factor(s) Study’s definition for obesity: BMI ≥ 30 kg/m2 The time when obesity has been measured: Unspecified Main variable used for determination of obesity: BMI Threshold used for definition: 30 Obesity frequency (absolute number): 123 Prognostic factor(s): BMI > 30 (obese) Outcome(s) Mechanical ventilation Outcome (prognostic factor) Mechanical ventilation (BMI > 30 (obese)) Follow‐up Number of patients followed completely for the outcome: 256 Number of obese patients followed completely for the outcome: 123 Number of non‐obese patients followed completely for the outcome: 133 Univariable unadjusted analysis for obesity Effect measure for obesity: NR Effect measure value (95% CI), P value: NR, < 0.0001 Multivariable analysis for obesity Modelling method: NR The set of prognostic factors used for adjustment: AST, BMI, DM, FIB‐4, FIB‐4 ≥ 2.6, FIB‐4 ≥ 3.25, history of respiratory disease, obesity Effect measure for obesity: Odds ratio Effect measure value (95% CI), P value: 4.5 (1.98, 10.27), 0.0003
Item	Authors' judgement	Support for judgement
Study Participation	Yes	Appendix 3
Study Attrition Mechanical ventilation	Unclear	Appendix 3
Prognostic Factor Measurement	Unclear	Appendix 3
Outcome Measurement Mechanical ventilation	Yes	Appendix 3
Confounding Bias Mechanical ventilation	Yes	Appendix 3
Statistical Analysis Bias	Unclear	Appendix 3