Thomson 2020.

Study characteristics
Notes	English title Clinical characteristics and outcomes of critically ill patients with COVID‐19 admitted to an intensive care unit in London: a prospective observational cohort study Study setting Start of study recruitment (MM/YYYY): 03/2020 End of study recruitment (MM/YYYY): 05/2020 Study design: Prospective cohort Study centre(s): Single centre/clinic/area within a country Number of centres, clinics or areas: 1 Study setting: Inpatient Number of participants recruited: 156 Sampling method: Consecutive participants Participants Female participants (absolute number): 44 Age measure, value: Median (IQR), 62 (54, 70) Inclusion criteria: All patients with laboratory‐confirmed SARS‐CoV‐2 infection admitted to the ICU from the first case until the cut‐off date for this study, 6 May 2020 Exclusion criteria: NR Smoking frequency: 117 Diabetes frequency: 52 Hypertension frequency: 81 Cardiovascular disease frequency: 26 Asthma frequency: NR Chronic obstructive pulmonary disease frequency: NR Other pulmonary disease frequency: 19 Immunosuppression frequency: NR Chronic kidney disease frequency: 23 Cancer frequency: NR Steroid administration frequency: NR Supplemental oxygen administration frequency: NR Other treatments (frequency): NR Prognostic factor(s) Study’s definition for obesity: Overweight or obese (BMI ≥ 25 kg/m2) The time when obesity has been measured: NR Main variable used for determination of obesity: BMI Threshold used for definition: 25 Obesity frequency (absolute number): 80 Prognostic factor(s): (BMI ≥ 25 kg/m2) Outcome(s) Mortality Outcome (prognostic factor) Mortality (BMI ≥ 25 kg/m2) Follow‐up Number of patients followed completely for the outcome: 156 Number of obese patients followed completely for the outcome: 89 Number of non‐obese patients followed completely for the outcome: 67 Univariable unadjusted analysis for obesity Effect measure for obesity: Odds ratio Effect measure value (95% CI), P value: 1.9 (0.87, 4.33), 0.1 Multivariable analysis for obesity Modelling method: Logistic regression The set of prognostic factors used for adjustment: Age, ethnicity, lowest P/F ratio on first ICU day, PaCO2 at time of lowest P/F ratio Effect measure for obesity: Odds ratio Effect measure value (95% CI), P value: 3.06 (1.16, 8.74), < 0.029
Item	Authors' judgement	Support for judgement
Study Participation	Yes	Appendix 3
Study Attrition Mortality	Yes	Appendix 3
Prognostic Factor Measurement	No	Appendix 3
Outcome Measurement Mortality	Yes	Appendix 3
Confounding Bias Mortality	No	Appendix 3
Statistical Analysis Bias	Unclear	Appendix 3