Yazdanpanah 2021.

Study characteristics
Notes	English title Impact on disease mortality of clinical, biological, and virological characteristics at hospital admission and overtime in COVID‐19 patients Study setting Start of study recruitment (MM/YYYY): 01/2020 End of study recruitment (MM/YYYY): 03/2020 Study design: Prospective cohort Study centre(s): Multiple centres/clinics/areas within a country Number of centres, clinics or areas: 25 Study setting: Inpatient Number of participants recruited: 246 Sampling method: Consecutive participants Participants Female participants (absolute number): 107 Age measure, value: Median (IQR), 62 (50, 73) Inclusion criteria: All hospitalised confirmed COVID‐19 patients Exclusion criteria: NR Smoking frequency: 13 Diabetes frequency: 39 Hypertension frequency: 73 Cardiovascular disease frequency: 48 Asthma frequency: 23 Chronic obstructive pulmonary disease frequency: NR Other pulmonary disease frequency: 21 Immunosuppression frequency: NR Chronic kidney disease frequency: 16 Cancer frequency: 14 Steroid administration frequency: 8 Supplemental oxygen administration frequency: 61 Other treatments (frequency): Remdesivir (4%), hydroxychloroquine (3%), lopinavir/ritonavir (27%) Prognostic factor(s) Study’s definition for obesity: NR The time when obesity has been measured: Some time after presentation Main variable used for determination of obesity: BMI Threshold used for definition: NR Obesity frequency (absolute number): 44 Prognostic factor(s): Obesity Outcome(s) Mortality Outcome (prognostic factor) Mortality (obesity) Follow‐up Number of patients followed completely for the outcome: 246 Number of obese patients followed completely for the outcome: 44 Number of non‐obese patients followed completely for the outcome: 202 Univariable unadjusted analysis for obesity Effect measure for obesity: Hazard ratio Effect measure value (95% CI), P value: 2.34 (1.23, 4.44), 0.009 Multivariable analysis for obesity Modelling method: Cox regression The set of prognostic factors used for adjustment: Age, sex Effect measure for obesity: Hazard ratio Effect measure value (95% CI), P value: 3.32 (1.7, 6.52), < 0.01
Item	Authors' judgement	Support for judgement
Study Participation	Unclear	Appendix 3
Study Attrition Mortality	Unclear	Appendix 3
Prognostic Factor Measurement	Unclear	Appendix 3
Outcome Measurement Mortality	Yes	Appendix 3
Confounding Bias Mortality	Yes	Appendix 3
Statistical Analysis Bias	Yes	Appendix 3