Figure 1. The molecular mechanism of LIN28B. LIN28B blocks Drosha from cleaving pri-let-7 miRNA into pre-let-7 miRNA in the nucleus. LIN28A/B can hinder the Dicer-dependent maturation of let-7 miRNA in the cytoplasm by binding let-7 miRNA loops via CSD and ZKD. Uridylation executed by the uridyl-transferase TUT4/Zcchc11 mediates let-7 degradation and translation of LIN28A/B targets. Created with BioRender.com.
