Table 1. All of the non-coding RNAs that affect Cisplatin response using the regulation of PI3K/AKT pathway.
| Gene | Mechanism | Target gene | Effect on the tumor cells | Clinical application | Samples | Study | Year |
|---|---|---|---|---|---|---|---|
| miR-181 | Downregulation | PTEN | Increased CDDP resistance | Diagnosis | 6 patients A549 cell line | Liu et al. [19] | 2018 |
| miR-1269b | Upregulation | PTEN | Increased CDDP resistance | Diagnosis | 32 patients HA549, SPCA1, H1299 H358, PC9, A549 cell lines | Yang et al. [20] | 2020 |
| miR-10a | Upregulation | PIK3CA | Increased CDDP resistance | Diagnosis and prognosis | 6 patients A549, H1299 cell lines | Huang et al. [21] | 2020 |
| miR-133b | Upregulation | EGFR | Increased CDDP sensitivity | Diagnosis | 24 patients A549 cell line | Li et al. [22] | 2018 |
| miR-221/222 | Downregulation | PTEN | Increased CDDP sensitivity | Diagnosis | A2780 cell line | Amini-Farsani et al. [23] | 2018 |
| miR-654-3p | Upregulation | PI3K/AKT | Increased CDDP sensitivity | Diagnosis | 20 patients IGROV-1, 293T cell lines | Niu et al. [24] | 2020 |
| miR-21 | Upregulation | PTEN | Increased CDDP resistance | Diagnosis | SGC7901 cell line | Yang et al. [25] | 2013 |
| miR-95-3p | Upregulation | EMP1 | Increased CDDP resistance | Diagnosis and prognosis | 92 patients SGC7901, AGS cell lines | Ni et al. [26] | 2021 |
| HOTAIR | Downregulation Upregulation |
miR-34a | Increased CDDP sensitivity | Diagnosis and prognosis | 27 patients SGC7901, MGC803 cell lines | Cheng et al. [27] | 2018 |
| FOXD1-AS1 | Upregulation | miR-466 | Increased CDDP resistance | Diagnosis | BGC-823, MKN28, MGC803, MKN45, AGS cell lines | Wu et al. [28] | 2021 |
| miR-4295 | Upregulation | LRIG1 | Increased CDDP resistance | Diagnosis | MKN-28, NCI-N87, SGC-7901, MKN-45, BGC-823 cell lines | Yan et al. [29] | 2018 |
| OIP5-AS1 | Upregulation | miR-340-5p | Increased CDDP resistance | Diagnosis | MG63-CR and SAOS2-CR cell lines | Song et al. [30] | 2019 |
| miR-497 | Upregulation | VEGFA | Increased CDDP sensitivity | Diagnosis | 74 patients SAOS-2 cell line | Shao et al. [31] | 2015 |
| miR-221 | Downregulation | PTEN | Increased CDDP sensitivity | Diagnosis | 60 patients SOSP-9607, SOSP-9901, MG63, SAOS-2, U20S, hFOB1.19 cell lines | Zhao et al. [32] | 2013 |
| miR-145 | Upregulation | AKT3 | Increased CDDP sensitivity | Diagnosis and prognosis | 30 patients EC109, EC9706, KYSE-150, KYSE-30, TE1 cell lines | Zheng et al. [33] | 2019 |
| MALAT1 | Downregulation | BRWD1 | Increased CDDP sensitivity | Diagnosis | Hela and C-33A cell lines | Wang et al. [34] | 2018 |
| miR-205-5p | Downregulation | PTEN | Increased CDDP sensitivity | Diagnosis | MG63, SAOS2 cell lines | Zhang et al. [35] | 2019 |
| DANCR | Upregulation | miR-33b5p, miR-33a-5p, miR-206, miR-1-3p, and miR-613 | Increased CDDP resistance | Diagnosis | U87MG, U251MG, LN18, U138MG cell lines | Ma et al. [36] | 2018 |