Table 5. Univariate and multivariate cox regression analysis of RNF43, YAP and clinicopathologic characteristics with overall survival and progression-free survival in cohort 1.

Characteristics	Overall survival				Progression-free survival
	Univariate		Multivariate		Univariate		Multivariate
	HR (95% CI)	P value	HR (95% CI)	P value	HR (95% CI)	P value	HR (95% CI)	P value
Age (<60 y vs. ≥60 y)	0.892 (0.412–1.928)	0.771			0.870 (0.402–1.882)	0.724
Gender (Male vs. Female)	1.513 (0.695–3.295)	0.297			1.536 (0.705–3.35)	0.280
WHO/ISUP Grading (1–2 vs. 3–4)	3.651 (1.627–8.194)	0.002	1.146 (0.456–2.883)	0.077	3.929 (1.748–8.828)	0.001	1.414 (0.572–3.494)	0.054
TNM stage (1–2 vs. 3–4)	7.868 (3.605–17.173)	<0.001	4.295 (2.952–9.532)	<0.001	8.143 (3.733–17.763)	<0.001	4.508 (2.017–9.182)	<0.001
SSIGN (1–4 vs. ≥5)	11.949 (5.468–26.111)	<0.001	9.704 (3.844–24.499)	<0.001	11.786 (5.398–25.735)	<0.001	8.207 (3.404–19.787)	<0.001
RNF43 expression (Low vs High)	0.986 (0.98–0.993)	<0.001	0.995 (0.987–1.004)	0.002	0.987 (0.98–0.993)	<0.001	0.995 (0.986–1.003)	0.003
YAP expression (Low vs. High)	1.079 (1.046–1.113)	<0.001	1.058 (1.018–1.1)	0.005	1.077 (1.045–1.111)	<0.001	1.042 (1.005–1.081)	0.003