Table 1 –

Cohort characteristics

Characteristic	N	N = 1883a
Age at diagnosis	1883	62 (56, 68)
Tumor location	1883
Metastasis		611 (32%)
Primary		1272 (68%)
Diagnosis Gleason grade	1578
≤6		134 (8.5%)
7		537 (34%)
≥8		907 (57%)
Disease stage at time of tumor sequencing	1858
Localized		502 (27%)
Regional nodal involvement		264 (14%)
Metastatic		1092 (59%)
Tumor mutation burden	1741	2.6 (1.0, 3.5)
≥10	1741	64 (3.7%)
MSI	1603
High		35 (2.2%)
Indeterminate/stable		1568 (98%)
Ashkenazi Jewish Heritage	1521	326 (21%)
Family history of cancer	1883	1584 (84%)
Family history of prostate cancer	1883	711 (38%)
Other cancer Dx	1883	347 (18%)
Race	1760
White		1516 (86%)
Black		144 (8.2%)
Asian		62 (3.5%)
Other		38 (2.2%)

Dx = diagnosis; IQR = interquartile range; MSI = microsatellite instability.

^aMedian (IQR); n (%).