Table 4. Risk-adapted treatment based on prognostic factors.
| Author (year) | Patients (n) | High risk vs. Low-risk (%) | Median Follow-up (months) | Relapse rate ACT vs. AS (%) | Desease-free survival ACT vs. AS (%) | Reference |
|---|---|---|---|---|---|---|
| Aparicio (2003) | 203 | 29.6 vs. 70.4 | 52 | 3.3 vs. 16.1 | 96.6 vs. 83.5 | [13] |
| Aparacio (2005) | 314 | 68.2 vs. 31.8 | 34 | 3.3 vs. 6.0 | 96.2 vs 93.4 | [73] |
| Aparicio (2011) | 214 | 33.0 vs. 67.0 | 34 | 1.4 vs 9.8 | 98.0 vs 88.1 | [74] |
| Aparicio (2018) | 135 | 47.4 vs. 52.6 | 33 | 1.6 vs. 7.0 | 98.2 vs. 92.0 | [75] |
Note: ACT: adjuvant chemotherapy; AS: active surveilance.