Table 1. A limited list of prominent factors that induce cadherin switching discussed in this review.

Gene	Cellular function	Expression under ADT	Effect on cadherin switching	Mechanism of action in cadherin switching	References
Zeb1	Transcription factor	Increases	Inducer	Direct and indirect regulation of E-cadherin/N-cadherin levels	[164,177,181–185]
Twist1	Transcription factor	Increases	Inducer	Direct and indirect regulation of E-cadherin/N-cadherin levels	[166,210,211]
Snail1/Snalil2	Transcription factor	Increases	Inducer	Direct and indirect regulation of E-cadherin N-cadherin levels	[165,169,229]
FoxC2	Transcription factor	Increases	Inducer	Indirectly inhibits E-cadherin expression—Directly increases N-cadherin levels.	[237,240,241]
Six1	Transcription factor	Increases	Inducer	Indirect regulation of E-cadherin/N-cadherin levels via increasing TGF-β signaling.	[246–248]
SPDEF	Transcription factor	Decreases	Repressor	Direct and indirect regulation of E-cadherin/N-cadherin levels	[138,255–257]
NDRG1	Cytoplasmic protein	Decreases	Repressor	Indirect regulation of E-cadherin/N-cadherin levels via inhibiting TGF-β signaling	[266,267]