TABLE 1:

Components of stochastic reaction-diffusion-dynamics model: list of components of the SRDDM along with their component type and functional role, including chromosomes (CHs), their sister kinetochores (KTs), centrosomes (spindle poles), microtubules (MTs), Ndc80 protein linkers anchored at the KTs, chromokinesin (CK) motors, Aurora B kinase, phosphatase kinase, cohesin rings, and cell membrane (see Figure 1 for graphical illustration; see also Supplemental Tables S1 and S2 for more detailed information for each component).

Model component	Component type	Functional role
Chromosome (CH)	Mechanical	Flexible genomic DNA-nucleoprotein packages segregating during mitosis
Kinetochore (KT) corona	Mechanical	Interactions with growing and shortening MTs through the plus ends attachment
Centrosome (CS)	Mechanical	Microtubule organizing center
Microtubule (MT)	Mechanical/Chemical	Pushing and pulling forces acting on CHs through MT plus end growth and shortening
Ndc80 linker	Mechanical/Chemical	Formation and disruption of noncovalent linkages between MT plus end and KT corona
Chromokinesin (CK) motor	Mechanical/Chemical	Formation of the reversible linkages between a MT and a CH arm
Aurora B kinase	Chemical	Phosphorylation of Ndc80 linkers
Phosphatase	Chemical	Dephosphorylation of Ndc80 linkers
Cohesin rings	Mechanical	CH arms constraining
Cell membrane	Mechanical	Delineation of the interior space of the cell