Table 4.

Top 15 differentially methylated CpG sites by marijuana consumption.

CpG	chr	position	Gene Symbol	Gene Group	On special occasions	Once per week	3–5 times per week	Regularly	F	P-Value	Adjusted P-Value
cg05107281	chr11	47072710	CSTPP1	Body	−0.004	−0.010	−0.014	0.001	9.4	1.6E–07	0.12
cg06499565	chr20	35374747	NDRG3	TSS1500	0.001	0.006	0.000	−0.001	8.7	5.7E–07	0.17
cg10054857	chr18	61816543	LINC00305	TSS1500	−0.004	−0.007	−0.002	−0.002	8.4	1.0E–06	0.17
cg24344693	chr10	133273964			−0.004	0.003	−0.001	−0.002	8.2	1.5E–06	0.17
cg20226924	chr5	133985272	SEC24A	Body	0.001	0.003	0.003	0.001	8.2	1.5E–06	0.17
cg05575921	chr5	373378	AHRR	Body	−0.003	−0.011	−0.012	−0.020	8.1	1.7E–06	0.17
cg21161138	chr5	399360	AHRR	Body	−0.004	−0.011	−0.009	−0.012	8.1	1.7E–06	0.17
cg19730404	chr9	139361517	SEC16A; SEC16A	ExonBnd;Body	−0.003	−0.001	0.001	−0.004	7.8	2.8E–06	0.25
cg19308363	chr12	116290566			0.006	0.005	−0.005	−0.015	7.7	3.4E–06	0.25
cg08258765	chr5	24841586	LOC340107	TSS1500	0.005	0.002	0.004	−0.002	7.7	3.8E–06	0.25
cg03838168	chrX	48433876	RBM3	Body	−0.003	−0.004	0.015	0.005	7.7	3.9E–06	0.25
cg16822035	chr13	113633379	MCF2L;MCF2L	Body;TSS1500	0.001	0.004	0.009	0.012	7.6	4.0E–06	0.25
cg11756734	chr12	9028945	A2ML1	3‘UTR	−0.005	0.002	−0.007	0.003	7.5	4.8E–06	0.26
cg08415592	chr22	36648973	APOL1	TSS200	0.008	0.016	−0.004	0.007	7.4	5.8E–06	0.26
cg17325792	chr1	77042560	ST6GALNAC3; ST6GALNAC3	3‘UTR;Body	0.003	0.001	0.003	−0.011	7.4	6.6E–06	0.26

Note: The CpG sites are annotated based on the chromosome (chr), the position (pos), the gene symbol from HGNC, and the gene group (based on the position of the CpG regarding the nearest gene). Each CpG site has a beta value for each consumer group vs non-consumers, a F-statistic (F), a nominal p-value, and an adjusted p-value by Bonferroni.