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. 2023 May 22;19(1):2209472. doi: 10.1080/21645515.2023.2209472

Table 4.

Statistical data of hematological examination of mice.

Group Days Mice WBC
(×109/L)		 NEU
(×109/L)		 LYM
(×109/L)		 MONO
(×109/L)		 EOS
(×109/L)		 BASO
(×109/L)		 RBC
(×1012/L)		 HGB
(g/dL)		 HCT
(%)		 RETIC%
(%)		 MCH
(pg)		 MCHC
(g/dL)		 PLT
(×109/L)
Negative control group 2 F 6 2.51 ± 0.67 0.61 ± 0.24 1.81 ± 0.47 0.02 ± 0.01 0.06 ± 0.03 0.00 ± 0.01 10.98 ± 0.56 16.0 ± 0.6 60.2 ± 3.9 2.60 ± 0.71 14.5 ± 0.4 26.5 ± 0.8 971 ± 62
M 6 1.97 ± 0.37 0.55 ± 0.14 1.34 ± 0.29 0.01 ± 0.00 0.07 ± 0.02 0.00 ± 0.00 10.48 ± 0.39 15.3 ± 0.7 58.7 ± 2.5 3.37 ± 0.81 14.6 ± 0.2 26.1 ± 0.7 1083 ± 155
58 F 9 1.78 ± 0.55 0.44 ± 0.11 1.27 ± 0.48 0.01 ± 0.01 0.05 ± 0.02 0.00 ± 0.00 10.40 ± 0.16 15.4 ± 0.3 49.4 ± 1.1 3.20 ± 0.50 14.8 ± 0.2 31.2 ± 0.3 1068 ± 59
M 9 1.54 ± 0.82 0.40 ± 0.15 1.09 ± 0.68 0.01 ± 0.01 0.03 ± 0.02 0.00 ± 0.00 10.20 ± 0.65 14.9 ± 0.7 49.4 ± 3.0 3.49 ± 0.45 14.7 ± 0.6 30.2 ± 1.0 1148 ± 71
112 F 6 1.32 ± 0.38 0.26 ± 0.07 0.96 ± 0.30 0.01 ± 0.01 0.08 ± 0.05 0.00 ± 0.00 10.07 ± 0.33 14.7 ± 0.5 46.7 ± 1.3 3.47 ± 0.51 14.6 ± 0.4 31.6 ± 1.3 1072 ± 115
M 6 1.20 ± 0.37 0.40 ± 0.16 0.74 ± 0.21 0.01 ± 0.01 0.04 ± 0.02 0.00 ± 0.00 9.69 ± 0.10 14.3 ± 0.2 47.3 ± 0.9 3.88 ± 0.45 14.7 ± 0.2 30.2 ± 0.4 1118 ± 80
Adjuvant control group 2 F 6 2.96 ± 0.61 0.55 ± 0.10 2.29 ± 0.55 0.01 ± 0.01 0.09 ± 0.08 0.01 ± 0.01 10.96 ± 0.32 15.8 ± 0.6 59.3 ± 2.7 3.77 ± 0.74* 14.4 ± 0.2 26.7 ± 0.5 898 ± 70
M 6 2.17 ± 0.44 0.74 ± 0.16 1.35 ± 0.28 0.02 ± 0.01 0.05 ± 0.02 0.00 ± 0.01 9.54 ± 0.52* 13.9 ± 0.6* 54.3 ± 5.1 3.16 ± 0.43 14.6 ± 0.5 25.8 ± 2.1 1080 ± 77
58 F 9 1.99 ± 0.47 0.50 ± 0.24 1.41 ± 0.33 0.01 ± 0.00 0.06 ± 0.03 0.00 ± 0.00 10.16 ± 0.32 15.1 ± 0.4 48.4 ± 1.7 3.24 ± 0.66 14.8 ± 0.2 31.1 ± 0.6 1069 ± 73
M 9 2.36 ± 0.84 0.87 ± 0.74* 1.42 ± 0.58 0.01 ± 0.01 0.05 ± 0.03 0.00 ± 0.00 10.13 ± 1.16 14.6 ± 1.5 49.4 ± 5.2 4.60 ± 3.01 14.4 ± 0.3 29.5 ± 0.8 1141 ± 225
112 F 6 1.48 ± 0.41 0.34 ± 0.11 1.08 ± 0.30 0.01 ± 0.01 0.05 ± 0.02 0.00 ± 0.00 10.04 ± 0.12 14.6 ± 0.2 47.4 ± 0.4 2.88 ± 0.25 14.6 ± 0.2 30.9 ± 0.5 1038 ± 82
M 6 1.65 ± 0.89 0.83 ± 0.82 0.72 ± 0.22 0.05 ± 0.06 0.05 ± 0.03 0.00 ± 0.00 10.17 ± 0.59 14.7 ± 0.8 48.2 ± 2.6 2.87 ± 0.26 14.5 ± 0.3 30.6 ± 0.6 1169 ± 76
Vaccine low dose group 2 F 6 2.87 ± 0.93 0.72 ± 0.34 2.06 ± 0.70 0.02 ± 0.01 0.06 ± 0.03 0.01 ± 0.01 10.17 ± 0.43 14.9 ± 0.7 55.7 ± 3.5 3.76 ± 0.66* 14.7 ± 0.2 26.8 ± 0.8 938 ± 56
M 6 2.85 ± 0.37** 0.80 ± 0.14 1.96 ± 0.39 0.02 ± 0.01 0.05 ± 0.03 0.01 ± 0.01 10.50 ± 0.61 15.0 ± 0.8 58.0 ± 4.4 2.94 ± 0.72 14.3 ± 0.1 25.9 ± 1.2 1074 ± 36
58 F 9 2.04 ± 0.96 0.65 ± 0.36 1.29 ± 0.72 0.02 ± 0.01 0.07 ± 0.05 0.00 ± 0.00 10.27 ± 0.37 15.1 ± 0.6 48.9 ± 1.8 3.46 ± 0.54 14.6 ± 0.3 30.8 ± 0.5 1101 ± 78
M 9 2.07 ± 0.46 0.64 ± 0.20 1.31 ± 0.33 0.02 ± 0.01 0.08 ± 0.04** 0.00 ± 0.00 10.26 ± 0.69 15.0 ± 0.8 49.9 ± 3.5 3.78 ± 0.48 14.7 ± 0.8 30.2 ± 1.7 1196 ± 108
112 F 6 1.65 ± 0.44 0.27 ± 0.12 1.31 ± 0.40 0.01 ± 0.01 0.06 ± 0.02 0.00 ± 0.00 10.13 ± 0.34 14.7 ± 0.5 47.3 ± 1.7 3.10 ± 0.55 14.5 ± 0.3 31.1 ± 0.6 1066 ± 63
M 6 1.30 ± 0.50 0.53 ± 0.33 0.71 ± 0.21 0.01 ± 0.01 0.04 ± 0.03 0.00 ± 0.00 9.74 ± 0.46 14.3 ± 0.5 46.6 ± 1.9 3.70 ± 0.58 14.7 ± 0.4 30.7 ± 0.8 1115 ± 78
Vaccine medium dose group 2 F 6 2.66 ± 0.27 0.58 ± 0.10 1.99 ± 0.17 0.02 ± 0.01 0.06 ± 0.02 0.01 ± 0.01 10.76 ± 0.34 15.7 ± 0.5 59.0 ± 2.8 3.66 ± 0.94 14.6 ± 0.2 26.7 ± 0.6 947 ± 45
M 6 2.85 ± 0.83* 0.98 ± 0.20** 1.80 ± 0.70 0.01 ± 0.01 0.05 ± 0.05 0.00 ± 0.01 10.67 ± 0.43 15.2 ± 0.8 58.6 ± 2.8 3.24 ± 0.92 14.2 ± 0.3 26.0 ± 0.5 1133 ± 66
58 F 9 1.88 ± 0.49 0.56 ± 0.17 1.24 ± 0.32 0.02 ± 0.01 0.06 ± 0.03 0.00 ± 0.00 9.95 ± 0.43 15.0 ± 0.4 47.1 ± 2.4 3.47 ± 0.49 15.1 ± 0.8 31.9 ± 1.9 1027 ± 68
M 9 1.98 ± 1.51 0.78 ± 0.72 1.12 ± 0.78 0.02 ± 0.03 0.05 ± 0.03 0.00 ± 0.00 9.96 ± 0.59 14.7 ± 0.8 48.6 ± 2.7 3.95 ± 0.80 14.8 ± 0.9 30.3 ± 1.8 1163 ± 90
112 F 6 1.47 ± 0.21 0.35 ± 0.08 1.04 ± 0.15 0.01 ± 0.01 0.07 ± 0.05 0.00 ± 0.00 10.29 ± 0.26 15.0 ± 0.4 48.2 ± 1.0 3.26 ± 0.35 14.6 ± 0.2 31.1 ± 0.2 1029 ± 99
M 6 1.57 ± 0.56 0.38 ± 0.12 1.13 ± 0.43 0.01 ± 0.01 0.05 ± 0.02 0.00 ± 0.00 10.10 ± 0.43 14.8 ± 0.3 49.2 ± 2.6 3.54 ± 0.58 14.7 ± 0.5 30.1 ± 1.5 1181 ± 42
Vaccine high dose group 2 F 6 2.18 ± 0.46 0.64 ± 0.22 1.46 ± 0.34 0.01 ± 0.01 0.05 ± 0.01 0.00 ± 0.00 10.56 ± 0.79 15.5 ± 0.8 57.7 ± 5.1 2.72 ± 0.44 14.7 ± 0.5 26.9 ± 1.2 994 ± 82
M 6 3.62 ± 1.10** 1.01 ± 0.15** 2.51 ± 0.96** 0.02 ± 0.01 0.07 ± 0.07 0.01 ± 0.01 10.55 ± 0.43 15.3 ± 0.5 58.2 ± 2.3 3.73 ± 0.92 14.5 ± 0.5 26.4 ± 0.9 1125 ± 88
58 F 9 1.90 ± 0.45 0.61 ± 0.16 1.19 ± 0.25 0.01 ± 0.01 0.08 ± 0.06 0.00 ± 0.01 10.16 ± 0.26 14.8 ± 0.3 48.2 ± 1.3 3.38 ± 0.34 14.6 ± 0.3 30.8 ± 0.4 1069 ± 46
M 9 2.17 ± 0.99 0.54 ± 0.12 1.52 ± 0.85 0.02 ± 0.01 0.07 ± 0.07 0.00 ± 0.01 10.90 ± 0.41* 15.5 ± 1.2 54.9 ± 5.0* 3.94 ± 0.42 14.2 ± 0.8 28.3 ± 1.8 1157 ± 154
112 F 6 1.65 ± 0.47 0.36 ± 0.13 1.20 ± 0.32 0.01 ± 0.00 0.08 ± 0.03 0.00 ± 0.00 10.31 ± 0.29 14.8 ± 0.5 48.5 ± 2.1 3.40 ± 0.73 14.3 ± 0.3 30.6 ± 1.0 1078 ± 51
M 6 1.77 ± 0.76 0.73 ± 0.58 0.93 ± 0.38 0.06 ± 0.08 0.05 ± 0.03 0.00 ± 0.00 10.03 ± 0.31 14.6 ± 0.5 48.2 ± 2.2 3.84 ± 1.18 14.5 ± 0.1 30.2 ± 0.6 1117 ± 69

All the date compared with the negative control group, * P < .05, ** P < .01.