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. 2023 May 10;14:1138524. doi: 10.3389/fimmu.2023.1138524

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Copyright © 2023 Xu, Pei, Cheng, Song, Yang, Li, He, Liang, Liu, Tan, Li, Pan and Meng

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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FOXM1 is highly expressed in HCC and is associated with high-frequency mutation and poor prognosis. (A) FOXM1 expression level in TCGA databases. (B) Difference of expression of FOXM1 in clinical samples. (C) The protein level of FOXM1 in healthy liver and primary HCC samples was detected by immunohistochemistry, bar 10 μm. The landscape profile of the top 10 mutated genes in the FOXM1 high expression group (D) and FOXM1 low expression group (E) from the TCGA database. (F) The proportion difference of clinical indices (including tumor, node, metastasis stages, and pathological grade) in the FOXM1 high and low expression groups from the TCGA LIHC dataset. (G) Prognostic relationship (OS and DFS) between FOXM1 and patients with HCC. (***p < 0.001, ****p < 0.0001).