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. 2023 May 10;14:1138524. doi: 10.3389/fimmu.2023.1138524

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Copyright © 2023 Xu, Pei, Cheng, Song, Yang, Li, He, Liang, Liu, Tan, Li, Pan and Meng

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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FOXM1 is highly correlated with m6a-related genes and has the ability to potentially transcribe IGF2BP1, IGF2BP2 and IGF2BP3. (A) Heat map of the correlation between FOXM1 and m6a-related genes expression. (B) Differences in m6a-related gene between FOXM1 high and low expression groups. (C) Volcano plots of mRNA that were differentially expressed between HCC and normal tissues. (D)Venn diagram of m6A-related genes positively associated with FOXM1 and DEGs in HCC. (E) Genome browser screenshots of the FOXM1 binding sites. The test group has two replicates, and the peaks shown are statistically significant. (F) Map of FOXM1 binding site sequence. (G) Schematic illustration of the potential FOXM1 binding sites (BS) in the IGF2BP3 promoter. (H) The scatter plot shows the correlation between the overlapping genes and FOXM1. (I) Kaplan-Meier overall survival curves of IGF2BP3. (*p < 0.05, **p < 0.01, ***p < 0.001).