TABLE 4.

Effect of CsA on viral replication in the bursa^a

Days p.i.	Chicken no.	No. of virus-infected cells/field ± SD
		Bursine 2-IBDV	CsA + Bursine 2-IBDV
5	1	122 ± 29	237 ± 51
	2	148 ± 39	232 ± 38
	3	154 ± 37	352 ± 67
	4	ND	340 ± 92
Mean		141 ± 17	290 ± 65*
7	1	93 ± 51	126 ± 37
	2	93 ± 52	106 ± 21
	3	75 ± 26	118 ± 31
Mean		87 ± 10	117 ± 10*

^aTen randomly selected fields (×400) per section were examined to enumerate cells positively stained with anti-IBDV antibodies. Positively stained cells were not detected in the bursae of virus-free chickens. The data were analyzed by the two-tailed t test. Statistical differences between mean values of the CsA-treated and untreated groups are indicated by asterisks (P < 0.05). ND, not determined.