Fig. 1. Schematic illustrations of application of the LMH for hard-to-heal wounds.

LMH was constructed by simultaneously using oxygen-produced Chlorella and antimicrobial beneficial B. subtilis into a hydrogel. The microecological hydrogel could fill the wound bed. The Chlorella in the microecological hydrogel could produce oxygen to enhance survival of the B. subtilis and relieve hypoxia, while the B. subtilis could control infections through releasing antimicrobial agents. The LMH could heal the infected diabetic wound using an antibacterial and by relieving hypoxia.