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Inhibition of tubulin polymerization and colchicine binding by 10, 11 and 18 as compared with CA-4
| Tubulin assemblya IC50 (μM) ± SD | Colchicine bindingb % inhibition ± SD |
||
|---|---|---|---|
| Compound | 50μM | 5 μM | |
| 10 | > 20 | 26 ± 7 | - |
| 11 | > 20 | 9.4 ± 2 | - |
| 18 | 19 | 23 ± 3 | - |
| CA-4 | 0.54 ± 0.06 | - | 98 ± 0.1 |
Tubulin was at 10 μM;
Tubulin and colchicine were at 1 and 5 μM concentrations, respectively.
