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. Author manuscript; available in PMC: 2024 Apr 1.
Published in final edited form as: Adv Nanobiomed Res. 2023 Feb 5;3(4):2200036. doi: 10.1002/anbr.202200036

Figure 2. Astrocyte and endothelial secretions influence brain-metastatic cancer cell migration.

Figure 2.

(A-B) Depiction of how (A) astrocyte and (B) microglia conditioned media was collected and placed in the device. The highest (N highest) and lowest (N lowest) count of cells from all replicates and conditions. (C-D) Cancer cell positions in BBN chips with (C) astrocyte and (D) microglia secretions plotted as distance (μm) to the endothelial barrier (0 μm). (E-F) Sphericity of cancer cells in BBN chips with (E) astrocyte and (F) microglia secretions. (G-H) Representative fluorescent confocal images of cancer cell extravasation in μBBN devices infused with (G) astrocyte or (H) microglia secretions after 2- and 9-Days, scale bar 125 μm. (C-F) p < 6.25*10–4 determined by Mann-Whitney significance tests with a Bonferroni correction. A list of replicates per condition are given in Table S1.