Table 3.
Diagnostic performance of the 5 evaluated diagnostic modalities
| Testing modalities | Sensitivity (%) (95% CI) |
Specificity (%) (95% CI) |
PPV (%) (95% CI) |
NPV (%) (95% CI) |
| Stool CMV-PCR alone | 70.4% (53.1–87.6) | 91.6% (86.0–97.2) | 70.4% (53.1–87.6) | 91.6% (86.0–97.2) |
| Plasma CMV-PCR alone | 66.7% (48.9–84.4) | 94.7% (90.2–99.2) | 78.3% (61.4–95.1) | 90.9% (85.2–96.6) |
| Positive stool CMV-PCR and positive plasma CMV-PCR | 55.6% (36.8–74.3) | 95.8% (91.7-99.8)a | 78.9% (60.6-97.3)a | 88.3% (82.1–94.5) |
| Positive stool CMV-PCR or positive plasma CMV-PCR | 81.5% (66.8-96.1)a | 90.5% (84.6–96.4) | 71.0% (55.0–86.9) | 94.5% (89.8-99.2)a |
| Tissue PCR | 85.2% (71.8–98.6) | 83.2% (75.6–90.7) | 59.0% (43.5–74.4) | 95.2% (90.6–99.8) |
a
The highest value for that diagnostic performance parameter.
CI, confidence interval; CMV, cytomegalovirus; PCR, polymerase chain reaction; PPV, positive predictive value; NPV, negative predictive value.