Figure 4.
NicheNet analyses of ileal CD8 TRM-cell interactions with other immune cells in health vs Crohn's disease (CD). (a) Putative ligand:receptor pairs on “sender” immune cells and receiver cell (CD8 TRM-1/Vδ2 γδ T cells), represented as Circos plots, in healthy subjects (left) or patients with CD (right). Colors indicate major immune cell type; each major cell type is also indicated in the caption between the 2 Circos plots. Specific immune cell subsets are labeled around the Circos plot. (b) Pathway analyses of enriched genes downstream of predicted ligand:receptor pairs, represented as reactome plots, in healthy subjects (left) or patients with CD (right). (c) Genes predicted to be induced in CD8 TRM-1/Vδ2 γδ T cells by predicted ligand:receptor interactions, represented as Circos plots, in healthy subjects (left) or patients with CD (right).