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. 2023 May 23;7(6):e0166. doi: 10.1097/HC9.0000000000000166

FIGURE 2.

FIGURE 2

Cholestatic liver injury is aggravated in Fxr/Tlr5 DKO mice. (A–G) Male WT (n = 5), Tlr5KO (n = 5), FxrKO (n = 16), and DKO (n = 18) mice were aged for 16 months, and cholestatic liver injury parameters in the serum were analyzed. (A) Alanine aminotransferase (ALT), (B) alkaline phosphatase (ALP), (C) total bilirubin, (D) gross serum depicting hyperbilirubinemia (ie, jaundice, yellowing of the serum), (E) conjugated bilirubin, (F) unconjugated bilirubin, and (G) total bile acids. Results are expressed as means ± SEM. *p < 0.05, **p < 0.01, ***p < 0.001, and ****p < 0.0001. Abbreviations: ALP, alkaline phosphatase; ALT, alanine aminotransferase; DKO, double knockout; WT, wild type.