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. Author manuscript; available in PMC: 2023 Jul 5.
Published in final edited form as: Nat Microbiol. 2023 Jan 5;8(1):28–39. doi: 10.1038/s41564-022-01282-x

Extended Data Fig. 4.

Extended Data Fig. 4.

(A) MICs for sulfamethoxazole, trimethoprim, and trimethoprim/sulfamethoxazole for the FA19 and 28BL pairs isogenic CanB variants. (B) Sulfamethoxazole susceptibility of MG1655Δcan complemented with isogenic CanB variants and induced with IPTG. (C) MICs for clinically relevant antibiotics for FA19 CanB19G and FA19 CanBE19G as determined by E-test and agar dilution plating. (D) gyrA mutations for spontaneous ciprofloxacin escapees or clean mutants of FA19 CanB19G and FA19 CanB19E, along with associated ciprofloxacin MIC.