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PP2A in T cell-mediated autoimmunity. PP2A is a serine/threonine phosphatase composed of trimolecular complex of scaffold subunit A, regulatory subunit B, and catalytic subunit C. PP2A promotes Th17 cell differentiation and increases Il17 expression contributing to the development of EAE as PP2A−/− mice were protected from EAE. Contrarily, PP2A−/− mice showed severe autoimmunity due to impaired immunosuppression by Tregs.
