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The molecular mechanism pattern was produced by Biorender (www.biorender.com). VEGF Vascular endothelial growth factor, S1P sphingosine-1-phosphate, S1PR1 sphingosine-1-phosphate receptor 1, PRP platelet-rich plasma, PRP-AS activated supernatants of PRP, PRP-Exos exosomes derived from PRP, FN1 fibronectin 1, AKT protein kinase B
