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. 2023 May 8;47(3):fuad020. doi: 10.1093/femsre/fuad020

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© The Author(s) 2023. Published by Oxford University Press on behalf of FEMS.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 4. — Guide for the development of adenosine analogues against T. brucei. The figure shows the role of different parts of the adenosine molecule on uptake, phosphorylation, cleavage, and deamination. The color codes indicate recognition motifs for the P1 and P2 transporters as well as for adenosine kinase. The white arrow indicates the swapped orientation of the OH and H groups on the 2´ carbon for arabinoside-based adenosine analogues. Abbreviations: hADA, human adenosine deaminase; AK, adenosine kinase; dCK, deoxycytidine kinase.