Table 1.
Target Genes of miRNA-372 Responsible for Its Tumor Suppressive/Oncogenic Action in Different Cancers.
| Gene | Location | Malignancy | Cell Lines | No. of Tissue sample | Outcomes | Protein | Mir- 372 expresstion | Reference | |
|---|---|---|---|---|---|---|---|---|---|
| RUVBL2 | 19q13.3 | Non-small cell lung cancer | N/A | CL 1-0 | N/A | Increases regulation of cell growth and transcription | RuvB-like 2 | ↑ | [165] |
| – | – | Lung adenocarcinoma | BEAS-2B | A549 | N/A | Increases growth, migration, invasion and decreases apoptosis | Wnt/β-catenin | ↑ | [166] |
| MTOR | 1p36.2 | Lung adenocarcinoma | BEAS-2B | A549 | N/A | Increases growth, migration, invasion and decreases apoptosis | mTOR | ↑ | [166] |
| CA12 | 15q22.2 | Lung adenocarcinoma | N/A | A549 | N/A | Patients with reduced CA12 in tumors have an increased risk of recurrence | CA12 proteins | ↑ | [167] |
| FGF9 | 13q12.11 | Lung squamous cell carcinoma | BEAS-2B | NCI–H520, SK-MES-1 and NCI–H1703 |
20 | Induces cell cycle arrest in G0/G1 stage Increases apoptosis |
FGF9 | ↑ | [168] |
| TP53 | 17p13.1 | nasopharyngeal carcinoma | N/A | 5–8F,C666-1, TW01 | N/A | Enhancing radiosensitivity while suppressing invasion and metastasis | p53 | ↓ | [169,170] |
| BAX | 19q13.33 | Nasopharyngeal Carcinoma | N/A | 5–8F,C666-1,TW01 | N/A | Induces mitochondrial dysfunction and death | BAX | ↓ | [169,170] |
| BCL2 | 18q21.33 | Nasopharyngeal Carcinoma | N/A | 5–8F,C666-1,TW01 | N/A | inhibition of cell progression due to a prolong duration of G1 phase, anti-apoptotic gene | Bcl-2 | ↓ | [169,170] |
| CDK2 | 12q13.2 | Nasopharyngeal Carcinoma | N/A | TW01 | N/A | Cell proliferation | Cdk-2 | ↓ | [170] |
| CCNA1 | 13q13.3 | Nasopharyngeal Carcinoma | N/A | TW01 | N/A | Cell proliferation | Cyclin-A1 | ↓ | [170] |
| PRKACB | 1p31.1 | Hepatocellular carcinoma | QSG-7701, Chang liver and HL-7702 | Huh-1 Huh-4, Hep3B, HepG2, Huh-7, SNU-449, SNU-475 |
14 | Decreases phosphorylation of CREB and CERB down regulates HULC | – | ↓ | [171] |
| ATAD2 | 8q24.13 | Hepatocellular carcinoma | LO2 | SMMC7721, QGY-7701, Bel-7402, PLC5, Huh7, HCCLM3, HepG2 |
129 | reduced their capacity for invasion and proliferation and led to a G1 phase arrest | tRNA-specific adenosine deaminase 2 | ↓ | [172] |
| MCL-1 | 1q21.2 | Hepatocellular carcinoma | N/A | HepG2 | 88 | Anti-apoptosis | Mcl-1 | ↓ | [173] |
| E2F1 | 20q11.22 | Hepatocellular carcinoma | N/A | HUH-7/DDP | 95 | Anti-apoptosis | E2f-1 | ↓ | [174] |
| CUL4B | Chromosome X | Bladder cancer | N/A | T24 253J 5637 RT112 RT4 SV-HUC-1 |
77 | Increased motility, invasiveness, stemness and chemoresistence | Cullin 4 B | ↓ | [125] |
| FXYD | 11q23.3 | Osteosarcoma | hfOB1.19 | O2OS SOSP-9607 MG-63 |
30 | Promotes tumor growth | FXYD6 | ↓ | [117] |
| LATS2 | 13q12.11 | Ovarian cancer | N/A | OVCAR3 A2780 |
N/A | Cell proliferation | Large tumor suppressor kinase2 | ↓ | [137] |
| LATS2 | 13q12.11 | Prostate cancer | N/A | DU145 PC3 |
25 | Tumor suppressor | Large tumor suppressor kinase2 | ↑ | [150] |
| LATS2 | 13q12.11 | Testicular germ cell tumor | N/A | N/A | N/A | Tumor suppressor | Large tumor suppressor kinase2 | ↑ | [26] |
| RhoC | 1p13.2 | Endometrial carcinoma | N/A | N/A | N/A | Cell growth Migration and invasion |
RAS homolog family member C | ↓ | [134] |
| TP65 | 11q3 | Prostate cancer | N/A | DU145 | 20 | Cell proliferation Invasion and migration |
P65 | ↓ | [149] |
| Sequestosome 1 | 5q35.3 | Ovarian cancer | N/A | OVCAR3 A2780 |
N/A | Cell proliferation | P62 | ↓ | [137] |
| CDK2 | 12q13.2 | Cervical cancer | N/A | HeLa C33A |
18 | Cell proliferation | Cyciln-dependent kinase 2 | ↓ | [129] |
| CDK2 | 12q13.2 | Endometrial cancer | N/A | N/A | N/A | Cell proliferation | Cyciln-dependent kinase 2 | ↓ | [134] |
| CCNA1 | 13q13.3 | Cervical cancer | N/A | HeLa C33A |
18 | Cell proliferation | Cyclin A1 | ↓ | [129] |
| CCNA1 | 13q13.3 | Endometrial caner | N/A | N/A | N/A | Cell proliferation | Cyclin A1 | ↓ | [134] |
| CCNA1 | 13q13.3 | Ovarian cancer | N/A | OVCAR3 A2780 |
N/A | Cell proliferation | Cyclin A1 | ↓ | [137] |
| ATAD2 | 8q24 | Ovarian cancer | N/A | OVCAR3 A2780 |
N/A | Cell proliferation and metastasis | ATPase Family AAA Domain Containing 2 | ↓ | [137] |
| ATAD2 | 8.q24 | Renal cell carcinoma | HK2 | Caki-1 786-O A498 ACHN Caki-2 |
52 | Cell proliferation | ATPase Family AAA Domain Containing 2 | ↓ | [143] |
| DKK1 | 10q21.1 | Ovarian cancer | N/A | OVCAR3 A2780 |
N/A | Cell proliferation | Dickkopf-related protein 1 | ↓ | [137] |
| IGF2BP1 | 17q21.32 | Renal cell carcinoma | HK2 | 769-P 786-O A498 SN12-PM6 |
30 | Cell proliferation and invasion | Insulin-like growth factor2 mRNA-binding protein1 | ↓ | [142] |
N/A: Not Applicable.
↑: Increased expression of miR-372.
↓: Decreased expression of miR-372.