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. 2023 Mar 13;28(4):1611–1621. doi: 10.1038/s41380-023-02017-y

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 2 — a, b Venn diagrams describe 846 and 1333 cell-specific DEGs across six major cell types in the Hip (a) and PFC (b). c DEGs (GF vs. SPF) downsampling analysis showed greater microglial gene dysregulations in the Hip (10 times repetition; Microglia vs Astrocyte, ***P = 4.9471E–11, Microglia vs Oligodendrocyte, *P = 0.0395, Microglia vs OPC, ***P = 3.4168E–21, Microglia vs Excitatory neuron, ***P = 1.0866E–19, Microglia vs Interneuron, ***P = 6.7238E–24; P values are from two-tailed Student’s t-test). d DEGs (GF vs. SPF) downsampling analysis showed greater microglial gene dysregulations in PFC, Microglia vs Astrocyte, ***P = 2.5005E–14, Microglia vs Oligodendrocyte, ***P = 1.1953E–17, Microglia vs OPC, *P = 4.019E–20, Microglia vs Excitatory neuron, ***P = 1.1021E–13, Microglia vs Interneuron, ***P = 1.562E–13; 10 times repetition; P values are from two-tailed Student’s t-test).