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. 2023 Mar 13;28(4):1611–1621. doi: 10.1038/s41380-023-02017-y

Fig. 5. Cross-species analysis described that microglia subpopulations regulated by the gut microbiota were associated with AD and MDD.

Fig. 5

a Circos graph shows microglial subpopulations highly associated with AD and MDD cross humans, mice and macaca (proportion of segment means –logFDR, Fisher’s exact tests, FDR-BH corrected). b The OFT showed no differences in locomotion activity in the three groups (SPF, n = 17; GF, n = 16; CGF, n = 16; data are mean ± SEM; NA means P = 0.109; P values are from ANOVA test). c GF mice displayed decreased immobility time in FST and restored partially in CGF mice (n = 6 in GF and CGF, n = 7 in SPF; data are mean ± SEM; GF vs. SPF, ***P = 3.00E–06; GF vs. CGF, **P = 0.0011, SPF vs. CGF, ***P = 6.10E–05; P values are from ANOVA post hoc analysis-Tamhane T2 test). d The decrease of spontaneous alternation rate of GF mice in the Y-maze test compared to SPF mice was restored in CGF mice (n = 10/group; data are mean ± SEM; GF vs. SPF, *P = 0.022; GF vs. CGF, *P = 0.012; P values are from ANOVA post hoc analysis-LSD test).