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. 2023 May 10;617(7962):842–850. doi: 10.1038/s41586-023-06049-w

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© The Author(s) 2023

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Fig. 3 — a, Relocation of PRP2 on the intron, RES complex dissociation from the translocated RNA and subsequent binding of PPIL4 to the latter. Pink, green and broken lines represent the PPT, the PPT region bound by SF3B1 within B^act, and the PPT-equivalent region visible only within the budding yeast B^act structure, respectively. b, Close-up view of the interfaces between PRP2 and other subunits in the B^act complex. c, The equivalent view and orientation of the B^AQR complex. d, SF3B1 exhibits primary and secondary hinged pockets for binding of BS-A and PPT, respectively. SF3B1 adopts a loose conformation in B^AQR, whereby the primary and secondary pockets are occupied and free, respectively.