Table 1.
Clinical Characteristics of Patients With Cirrhosis Compared with Chronic Liver Disease Without Cirrhosis and Healthy Controls
| Variables, median (range) | Cirrhosis (n = 22) | CLD without cirrhosis (n = 8) | Healthy controls (n = 4) | ||
|---|---|---|---|---|---|
| Age (y) | 59 (34–79) | 38 (24–66)a | 55 (47–69) | ||
| Sex (m:f) | 14:8 | 5:3 | — | ||
| Underlying liver disease(s) [%] | ALD HCV NAFLD PBC Wilson’s disease Hemochromatosis Unknown |
11 [50] 4 [18] 2 [9] 2 [9] 1 [5] 1 [5] 1 [5] |
HBV NAFLD AIH |
4 [50] 3 [37.5] 1 [12.5] |
NA |
| Death (1 year) | 3 [14] | — | — | ||
| Child-Pugh | 8 (5–11) | 5 (5–5) | NA | ||
| MELD | 14 (6–29) | 6 (6–6) | NA | ||
| BMI (kg/m2) | 27 (17–32) | — | — | ||
| Na+ (mmol/L) | 138 (120–144) | 139 (137–142) | 140 (138–142) | ||
| K+ (mmol/L) | 3.9 (3.0–5.1) | 3.8 (3.7–4.0) | 3.95 (3.40–4.20) | ||
| Creatinin (μmol/L) | 84 (47–171) | 70.5 (61.0–83.0) | 83.5 (73.0–93.0) | ||
| Urea (mmol/L) | 5.9 (3.1–14.7) | 3.7 (3.5–3.9) | 6.75 (4.8–7.6) | ||
| Bilirubin (μmol/L) | 34 (8–147) | 16 (5–32) | 9.5 (6–12)b | ||
| AST (U/L) | 49 (16–168) | 28 (17–133) | 23 (22–27)b | ||
| ALT (U/L) | 29.5 (7.0–114.0) | 27 (11–207) | 30.5 (15.0–35.0) | ||
| GGT (U/L) | 85 (26–1013) | 26 (10–272) | 119 (20–133) | ||
| AP (U/L) | 117 (49–483) | 76 (35–106) | 56 (33–93)c | ||
| INR | 1.45 (0.90–2.30) | 1 (1–1)a | — | ||
| Albumin (g/L) | 26.5 (19.0–39.0) | 39.8 (37.0–44.4)d | 39 (38–40)e | ||
| Hemoglobin (g/L) | 99.5 (7.2–152.0) | 142 (113–164)d | — | ||
| Hematocrit (%) | 0.314 (0.242–0.440) | 0.42 (0.35–0.5)a | — | ||
| Leukocytes (G/L) | 5.05 (2.40–70.0) | 5.4 (4.3–6) | — | ||
| Neutrophils (G/L) | 3.6 (1.6–41.3) | 48.9 (48.6–55.1)f | — | ||
| Eosinophils (G/L) | 0.29 (0.017–0.91) | 3.9 (2.2–5.7) | — | ||
| Basophils (G/L) | 0.37 (0.001–0.28) | 0.7 (0.6–1.3) | — | ||
| Lymphocytes (G/L) | 1.55 (0.4–2.5) | 2.3 (1.6–2.5) | — | ||
| Monocytes (G/L) | 0.62 (0.23–7.49) | 5.8 (5.7–7.3) | — | ||
| Platelets (G/L) | 100.5 (8.5–341) | 218 (172–235)a | — | ||
| CRP (mg/L) | 9 (0.4–67) | 2 (0.6–5.4)f | 1.35 (0.70–2.40)b |
NOTE. Data indicated as median with (minimum and maximum) and [percentage].
AIH, autoimmune hepatitis; ALD, alcoholic liver disease; ALT, alanine aminotransferase; AP, alkaline phosphatase; AST, aspartate aminotransferase; BMI, body mass index; CRP, C-reactive protein; GGT, gamma-glutamyl transferase; HBV, hepatitis B virus; HCV, hepatitis C virus; INR, international normalized ratio; MELD, Model for End-Stage Liver Disease; NAFLD, nonalcoholic fatty liver disease; PBC, primary biliary cirrhosis.
P = .01.
P = .01.
P = .05.
P = .001 indicate cirrhosis vs CLD without cirrhosis.
P = .001 indicate cirrhosis vs healthy controls; comparisons by Mann-Whitney U tests.
P = .05.