Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2023 May 24;13:8391. doi: 10.1038/s41598-023-35196-3

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

PMC Copyright notice

Metabolic phenotyping in 24 M Mrpl54^+/− and wild type mice. (a) Body composition (g) by EchoMRI in 24 M male Mrpl54^+/− (n = 12) and WT (n = 10) and female Mrpl54^+/− (n = 11) and WT (n = 13). (b) Mean VO₂ (L/h) by CLAMS and body mass ANCOVA analysis (insets) in 24 M old male Mrpl54^+/− (n = 10) and WT (n = 9) and female Mrpl54^+/− and WT. (c) Mean RER by CLAMS in 24 M old male Mrpl54^+/− (n = 10) and WT (n = 9) and female Mrpl54^+/− and WT. (d) Mean ambulatory motion (beam break counts) in 24 M old male Mrpl54^+/− (n = 9) and WT (n = 9) and female Mrpl54^+/− (n = 10) and WT (n = 13). (e) Mean duration (min) on an endurance treadmill for 24 M old mice male Mrpl54^+/− (n = 6) and WT (n = 7) and female Mrpl54^+/− (n = 7) and WT (n = 9). (f) Mean blood glucose level (mmol/L) over time in response to an oral glucose challenge (OGTT) in 24 M old male Mrpl54^+/− (n = 10) and WT (n = 8) and female Mrpl54^+/− (n = 10) and WT (n = 12). (g) Mean blood glucose level (mmol/L) and AUC (insets) over time in response to intraperitoneal insulin challenge (ipITT) in 24 M old male Mrpl54^+/− (n = 8) and WT (n = 8) and female Mrpl54^+/− (n = 10) and WT (n = 11). (h) Mean rectal temperature (°C) in response to a 4-h 4 °C cold challenge in 24 M old male Mrpl54^+/− (n = 4) and WT (n = 3) and female Mrpl54^+/− (n = 4) and WT (n = 7). (i) Mean heart rate (beats/min) and blood pressure (mmHg) in 24 M old male Mrpl54^+/− (n = 6) and WT (n = 5) and female Mrpl54^+/− (n = 5) and WT (n = 8). (j) Relative organ weights (% body mass) in 24 M necropsied male Mrpl54^+/− (n = 4–5) and WT (n = 3–4) and female Mrpl54^+/− (n = 3) and WT (n = 6–7). Graphs show mean ± SEM; male WT (blue); male Mrpl54^+/− (light blue); female WT (orange); and female Mrpl54^+/− (light orange).