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. 2023 May 24;13:8391. doi: 10.1038/s41598-023-35196-3

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Life expectancy and lifespan in male and female Mrpl54^+/− mice. (a) Kaplan Meier survival curves showed no difference in overall lifespan (top 10% of surviving animals) between either male Mrpl54^+/− (n = 81) and WT (n = 112) or female Mrpl54^+/− (n = 80) and WT (n = 99) mice. No differences were observed in median life expectancy between Mrpl54^+/−and WT for either males or females. (b) Kaplan Meier survival curves showed no difference in overall lifespan between either individual-housed male Mrpl54^+/− (n = 39) and WT (n = 40) or group-housed male Mrpl54^+/− (n = 42) and WT (n = 72). Individual-housed Mrpl54^+/− male mice had better median life expectancy compared to individual-housed WT, with no difference in median life expectancy between group-housed male Mrpl54^+/− and WT.