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. 2023 May 24;13:8391. doi: 10.1038/s41598-023-35196-3

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Biochemical profiling of Mrpl54^+ / − and wild type mouse liver. (a) Oxygraph respiration analysis of isolated liver mitochondria showed no difference in state 2, state 3, or maximal respiration between Mrpl54^+/− (n = 6) and WT (n = 3). (b) Semiquantitative western blot analysis of HSP60 expression in isolated liver mitochondria showed no difference between Mrpl54^+/− (n = 2) and WT (n = 3). (c) Mass spectrometry analysis of protein from isolated liver mitochondria showed no difference between levels (label-free quantification, LFQ) of nDNA- and mtDNA-encoded protein subunits of ETC complex IV between Mrpl54^+/− (n = 3) and WT (n = 3). Graphs show mean ± SEM; male WT (blue); male Mrpl54^+/− (light blue).