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. 2023 May 18;92:104621. doi: 10.1016/j.ebiom.2023.104621

Fig. 3.

Fig. 3

Rate of CHDM growth in relation to age and metabolic dysfunction. (a) VAF in relation to age for the 32 most important trajectories. The average mixed linear model (MLM) regression line and equation is shown in black. All individual MLM regression lines are shown in various colours, in purple the trajectory with maximum slope and accompanying equation, in orange the trajectory with minimum slope and accompanying equation. (b) VAFs and slopes for CHDMs in DNMT3A [p.(Arg822Cys)] in 4 individuals and DNMT3A [p.(Arg882His)] in 2 individuals. (c) Heatmap of Spearman R correlations between all individual trajectory effect estimates from our MLM to averaged (based on the three first follow-up timepoints) metabolic clinical parameters. (d) Positive Spearman R correlation between individual trajectory effect estimates and insulin. (e) Positive Spearman R correlation between individual trajectory effect estimates and HOMA-index. (f) Negative Spearman R correlation between individual trajectory effect estimates and HDL-C.