Table 1.
Characteristics at time of DNA in the single-timepoint usual care and bariatric surgery groups.
| Single-timepoint usual care | Single-timepoint bariatric surgery | Pa | |
|---|---|---|---|
| CHDM carriers, n (%) | 216 (20.6) | 189 (22.5) | 0.338 |
| Number of CHDMs, n (% of CHDM carriers) | 0.202 | ||
| 1 | 172 (79.6) | 165 (87.3) | |
| 2 | 34 (15.7) | 18 (9.5) | |
| 3 | 7 (3.2) | 5 (2.6) | |
| 4 | 3 (1.4) | 1 (0.5) | |
| CHIP, n (% of CHDMs) | 71 (32.9) | 66 (34.9) | 0.663 |
| Male sex, n (%) | 59 (27.3) | 59 (31.2) | 0.452 |
| Age, yrs. (mean (SD)) | 55.0 (6.98) | 55.2 (6.66) | 0.710 |
| BMI, kg/m2 (mean (SD)) | 40.4 (5.26) | 34.4 (5.28) | <0.001 |
| Waist to hip-ratio (mean (SD)) | 0.98 (0.08) | 0.95 (0.08) | 0.001 |
| Plasma glucose, mmol/L (mean (SD)) | 5.94 (2.38) | 5.27 (1.71) | 0.002 |
| Type 2 diabetesb, n (%) | 49 (22.8) | 28 (14.8) | 0.056 |
| Insulin, mU/L (mean (SD)) | 17.3 (12.4) | 11.9 (8.21) | <0.001 |
| HOMA-index, mU/L∗mmol/L (mean (SD)) | 4.73 (4.13) | 3.08 (3.51) | <0.001 |
| Total cholesterol, mmol/L (mean (SD)) | 5.48 (1.05) | 5.55 (1.05) | 0.513 |
| HDL-cholesterol, mmol/L (mean (SD)) | 1.38 (0.33) | 1.61 (0.45) | <0.001 |
| LDL-cholesterolc, mmol/L (mean (SD)) | 3.21 (0.86) | 3.25 (0.98) | 0.703 |
| Triglycerides, mmol/L (mean (SD)) | 1.95 (1.37) | 1.53 (0.78) | <0.001 |
| High-sensitive CRP, mg/L (mean (SD)) | 7.89 (8.18) | 4.52 (7.12) | <0.001 |
| Systolic blood pressure, mmHg (mean (SD)) | 142 (18.7) | 140 (18.0) | 0.427 |
| Diastolic blood pressure, mmHg (mean (SD)) | 82.9 (9.76) | 85.3 (10.5) | 0.019 |
| Hypertensiond, n (%) | 150 (73.2) | 134 (70.9) | 0.697 |
| Daily smoker, n (%) | 54 (25.0) | 49 (25.9) | 0.921 |
a
T-test for continuous variables, Chi2-test for categorical variables.
b
Based on blood glucose and/or use of anti-diabetes medication.
c
Based on Friedewalds equation: LDL-cholesterol = Total cholesterol−(Triglycerides/2.2)−HDL-cholesterol.
d
Based on systolic blood pressure ≥140 or diastolic blood pressure ≥90 or self-reported use of blood pressure lowering medication.