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. 2023 May 24;13:173. doi: 10.1038/s41398-023-02476-5

Fig. 4. Acute systemic administration of 7,8-DHF partially reversed stress-induced spatial memory loss.

Fig. 4

A The experimental timeline of the behavioral procedure and ANA-12 injection. B Schematic showing the acute intraperitoneal injection of ANA-12 into adult C57BL/6 N mice. C In the SOR test, although both CT and ANA-12-treated mice showed preference to the novel location, CT mice had higher preference index than ANA-12-treated mice. D ANA-12-treated mice had a lower spontaneous alternation ratio in the Y-maze test than control mice. E The experimental timeline of the behavioral procedure and 7,8-DHF injection after ELS exposure. F Schematic showing the acute intraperitoneal injection of 7,8-DHF into adult C57BL/6 N mice. G In the SOR test, except that the ELS + Veh group failed to recognize the object placed in novel location, the other three groups performed well. H In the Y-maze test, microinjection of 7,8-DHF in DG did not significantly affect spatial working memory. AAR alternate arm return, Acc. acclimation, CT control, DHF 7,8-dihydroxyflavone, ELS early-life stress, PND postnatal day, SA spontaneous alternation, SAR same arm return, SOR spatial object recognition, Veh vehicle. *p < 0.05, **p < 0.01, unpaired t test; #p < 0.05, ##p < 0.01, ###p < 0.001, one-sample t test.