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. 2023 May 24;14:2985. doi: 10.1038/s41467-023-38426-4

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 5 — a t-SNE plot of M/PDA and SRCC cells (coloured by cell type). b Pathway enrichment analysis plots of DEGs upregulated in M/PDA and SRCC cells. Compared with M/PDA cells, the DEGs upregulated in SRCC cells were mainly enriched in abnormally activated cancer-related signalling pathways (e.g., transcriptional misregulation in cancer, pathways in cancer and microRNAs in cancer) and were closely associated with signalling pathways of immune escape (e.g., TNF signalling pathway, TGF-β signalling pathway and NF-kB signalling pathway). c Heatmap plot of DEGs in M/PDA and SRCC cells. d Heatmap plot of DEGs in MKN-45 and NUGC4 cells. e KEGG pathway enrichment analysis of MKN-45 and NUGC4 cells among DEGs. f Differences between M/PDA and SRCC cells in terms of cell proliferation, cell adhesion, immune surveillance, and immune escape. M/PDA cells had high proliferation and immune surveillance capabilities, while SRCC cells had low cell adhesion and high immune escape capabilities (t-test, p < 0.001). n = 10 (include 3 samples in MDA and PDA groups, respectively; and 4 samples in GSRC group). Data are presented as mean values ± SEM. In the box plot, the black dots represent outliers, the error bars represent SEM, the box midpoints represent means and the boxes represent inter-quartile positions. p values were calculated using the two-sided unpaired Student’s t-test, p values < 0.05 were considered to indicate significance: ***p < 0.001. Source data are provided as a Source Data file.