Table 2.
Adverse events.
| Baseline | 1HR | D1 | D3 | D7 | D14 | D28 | |
|---|---|---|---|---|---|---|---|
| Ketamine, n = 10 | |||||||
| Vivid dreams | 6 | 0 | 3 | 4 | 6 | 6 | 4 |
| Dream-like visions | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
| Blurry/double vision | 2 | 0 | 2 | 1 | 3 | 2 | 1 |
| Jerky muscle movements | 1 | 1 | 2 | 1 | 3 | 2 | 1 |
| Nausea or vomiting | 3 | 2 | 0 | 4 | 2 | 3 | 1 |
| Diarrhea | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
| Hallucinations/Misperceptions | 0 | 0 | 1 | 0 | 0 | 0 | 0 |
| Larynogspasm | 2 | 0 | 0 | 0 | 0 | 0 | 0 |
| Other—Headaches | 0 | 1 | 0 | 0 | 1 | 0 | 0 |
| Other—Fatigue/Unsteadiness | 0 | 0 | 2 | 0 | 0 | 0 | 0 |
| Other—Increased thirst | 0 | 0 | 1 | 0 | 0 | 0 | 0 |
| Other—Body pain | 1 | 1 | 1 | 1 | 0 | 0 | 0 |
| Midazolam, n = 12 | |||||||
| Vivid dreams | 5 | 1 | 2 | 4 | 1 | 4 | 1 |
| Dream-like visions | 2 | 0 | 0 | 0 | 0 | 0 | 0 |
| Blurry/double vision | 1 | 1 | 1 | 1 | 0 | 0 | 0 |
| Jerky muscle movements | 0 | 1 | 1 | 0 | 0 | 0 | 0 |
| Nausea or vomiting | 2 | 1 | 3 | 2 | 2 | 1 | 1 |
| Diarrhea | 0 | 0 | 0 | 1 | 2 | 1 | 2 |
| Hallucinations/Misperceptions | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
| Larynogspasm | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
| Other - Headaches | 0 | 1 | 2 | 1 | 2 | 1 | 1 |
| Other - Fatigue/Unsteadiness | 1 | 2 | 3 | 1 | 0 | 0 | 0 |
| Other - Increased thirst | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
| Other - Body pain | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Adverse event frequencies before (Baseline), just after (1 hr post-infusion), and after medication infusion on Days 1, 3, 7, 14, and 28.