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. 2023 May 24;14(5):341. doi: 10.1038/s41419-023-05862-5

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 2 — A The expression level of PAXIP1-AS1 in gastric tissue was determined from the GEPIA database, using the TCGA tumour matching TCGA and GTEx normal data. B, C PAXIP1-AS1 expression was detected by qPCR in 75 pairs of human GC and adjacent normal mucosal tissues. Error bars represent the standard deviation (SD) in three independent experiments. ****P < 0.001. N, Normal; C, Cancer. D The expression level of PAXIP1-AS1 in immortalised gastric mucosal cell line GES-1 and GC cell lines was obtained using qPCR. One-way analysis of variance (ANOVA) and Dunnett’s T3 multiple comparison test were used to compare the expression difference among GES-1 and all GC cell lines. ***P < 0.01. E Subcellular localisation of PAXIP1-AS1, GAPDH, and NEAT1 in GES-1 and MKN-74 cells. GAPDH mRNA and NEAT1 mRNA were used as controls for the cytoplasmic and nuclear fractions, respectively. F Representative In situ hybridization (ISH) images of PAXIP1-AS1 expression in normal gastric mucosa and GC tissues. Scale bar, 100 μm. G PAXIP1-AS1 expression level was lower in T3–4 than in T1–2 GC samples. **P < 0.05. H Expression of PAXIP1-AS1 in different clinical GC stages. **P < 0.05. stages I–II vs. stages III–IV.