Table 3.
Changes in MIC of antibiotics during in vitro human digestion.
| Bacterial strain | Antibiotic | MIC (μg/mL) |
|||
|---|---|---|---|---|---|
| Before digestion |
In vitro human digestion phase |
||||
| Mouth | Stomach | Small intestine | |||
| SA RN4220 | Tetracycline | 2 (S) | 4 (S) | 8 (I) | 16 (R) |
| Ofloxacin | 1 (S) | 2 (I) | 2 (I) | 8 (R) | |
| Penicillin | >2 (R) | >2 (R) | >2 (R) | >2 (R) | |
| MRSA | Tetracycline | 8 (I) | 16 (R) | 16 (R) | 16 (R) |
| Ofloxacin | 4 (R) | 4 (R) | 4 (R) | 8 (R) | |
| Penicillin | >2 (R) | >2 (R) | >2 (R) | >2 (R) | |
SA RN4220, fluoroquinolone-susceptible restriction-deficient mutant of Staphylococcus aureus, MRSA, methicillin-resistant S. aureus, R, resistant; I, intermediately resistant; S, susceptible; MIC, minimum inhibitory concentration.
MIC was determined according to the Clinical and Laboratory Standards Institute (CLSI) guidelines for Staphylococcus spp.