Table 4.
List of preclinical studies investigating the use of combination OV and adoptive cell therapy
| Oncolytic virus | Transgene(s) | Cells | Cancer type(s) | Reference |
|---|---|---|---|---|
| Adenovirus (Ad5Delta24) | CCL5, IL-15 | GD2-CAR-T | neuroblastoma | Nishio (2014)19 |
| Vaccinia virus (vvDD) and vesicular stomatitis virus (VSVDeltaM51) | N/A | HER2-CAR-T (loaded with the OV) | breast cancer | VanSeggelen (2015)20 |
| HSV-1 (oHSV-1) | N/A | EGFR-CAR NK | breast cancer brain metastases | Chen (2016)21 |
| HSV-1 (oHSV-1) | N/A | NK cells | glioblastoma | Yoo (2016)22 |
| Adenovirus (Ad5/3Delta24) | IL12, anti-PDL1 expressed by co-injected helper Ad | HER2-CAR-T | head and neck squamous cell carcinoma | Rosewell Shaw (2017)23 |
| Adenovirus (Ad5/3Delta24) | Anti-PDL1 expressed by co-injected helper Ad | HER2-CAR-T | prostate, squamous cell carcinoma | Tanoue (2017)24 |
| Adenovirus (ICOVIR15K) | EGFRxCD3 bispecific | folate receptor-CAR-T | pancreatic ductal carcinoma/colorectal carcinoma | Wing (2018)25 |
| Adenovirus (Ad5/3E2FDelta24) | TNFα, IL-12 | mesothelin-CAR-T | pancreatic ductal carcinoma | Watanabe (2018)26 |
| Vaccinia virus (vvDD) | CXCL-11 | mesothelin-CAR-T | lung cancer | Moon (2018)27 |
| Chimeric vaccinia virus (CF33) | truncated CD19 | CD19-CAR | breast cancer | Park (2019)28 |
| Vesicular stomatitis virus | mIFNβ | mEGFRvIII | murine melanoma | Evgin (2020)17 |
| Vaccinia Western Reserve | CCL5 | CCR5-NK | various carcinomas | Li (2020)29 |
| Adenovirus (Ad5/3Delta24) | CD44v6xCD3 bispecific, IL-12, anti-PDL1 expressed by co-injected helper Ad | HER2-CAR-T | pancreatic ductal adenocarcinoma, squamous cell carcinoma | Porter (2020)30 |
| Adenovirus (rAd.sT) | TGFb decoy | mesothelin-CAR-T | breast cancer | Li (2020)31 |
| Vaccinia virus | CD19 | CD19-CAR-T | Melanoma | Aalipour (2020)32 |
| Adenovirus | CD19 tag | CD19-CAR-T | liver cancer | Tang (2020)33 |
| Adenovirus (Ad5/3Delta24) | IL12, anti-PDL1 expressed by co-injected helper Ad | HER2-CAR-T | pancreatic cancer | Rosewell Shaw (2021)34 |
| Vesicular stomatitis virus (VSVDeltaM51) | IL-15 | NKT | pancreatic cancer | Nelson (2022)35 |
| HSV-1 (G47Δ) | N/A | Lp2-CAR-T | Glioblastoma | Chalise (2022)36 |
| Vesicular stomatitis virus, reovirus | mIFNβ (VSV) | mEGFRvIII | murine melanoma, glioma | Evgin (2022)37 |
| HSV-1 | OX40L, IL-12 | TILs | colon cancer, pancreatic cancer | Ye (2022)38 |