Table 4.

Statistically significant upregulated reactome pathways after multi− omic analysis of PGVG + phytol lungs

Upregulated reactome
Name	P-value
Crosslinking of collagen fibrils	2.47E−06
Platelet Adhesion to exposed collagen	2.96E−06
GPVI-mediated activation cascade	0.0000237
Degradation of the extracellular matrix	0.000131
Peptide ligand-binding receptors	0.000439
Chemokine receptors bind chemokines	0.00113
Class A/1 (Rhodopsin-like receptors)	0.00182
GPCR ligand binding	0.00414
Interleukin-1 processing	0.00449
Cytokine Signaling in Immune system	0.0245
GPCR downstream signaling	0.027
Activation of Matrix Metalloproteinases	0.0275
Signaling by GPCR	0.039
Interleukin-1 signaling	0.0398