Table 5.
Statistically significant downregulated reactome pathways after multi-omic analysis of PGVG + phytol lungs
| Downregulated reactome | |
|---|---|
| Name | P-value |
| Activation of Chaperone Genes by ATF6-alpha | 0.00449 |
| Signal Transduction | 0.00487 |
| Formyl peptide receptors bind formyl peptides and many other ligands | 0.00538 |
| Activation of C3 and C5 | 0.00628 |
| Terminal pathway of complement | 0.00628 |
| Activation of Genes by ATF4 | 0.00628 |
| Activation of Chaperones by ATF6-alpha | 0.00717 |
| Regulation of Gene Expression by Hypoxia-inducible Factor | 0.00806 |
| Dissolution of Fibrin Clot | 0.00896 |
| Peptide ligand-binding receptors | 0.0114 |
| Apoptotic cleavage of cell adhesion proteins | 0.0116 |
| PERK regulated gene expression | 0.0116 |
| TRAF3-dependent IRF activation pathway | 0.0125 |
| NICD traffics to nucleus | 0.0134 |
| Beta-catenin phosphorylation cascade | 0.0134 |
| Notch-HLH transcription pathway | 0.0134 |
| Cellular responses to stress | 0.024 |
| Cellular response to hypoxia | 0.024 |
| Regulation of Hypoxia-inducible Factor (HIF) by Oxygen | 0.024 |
| TRAF6 mediated IRF7 activation | 0.0249 |
| Myogenesis | 0.0275 |
| CDO in myogenesis | 0.0275 |
| Adherens junctions interactions | 0.0275 |
| Class A/1 (Rhodopsin-like receptors) | 0.0288 |
| Complement cascade | 0.0293 |
| Apoptotic cleavage of cellular proteins | 0.038 |
| NOTCH1 Intracellular Domain Regulates Transcription | 0.0441 |
| Constitutive Signaling by NOTCH1 HD + PEST Domain Mutants | 0.0458 |
| GPCR ligand binding | 0.0489 |
| Transcriptional Regulation of White Adipocyte Differentiation | 0.0493 |
| Developmental Biology | 0.0493 |