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. 2022 Jun 16;46(3):100546. doi: 10.1016/j.bj.2022.06.002

Fig. 5.

Fig. 5

Entresto and dapagliflozin therapy ameliorated inflammatory cell infiltration in LV myocardium by day 3 after acute IR induction. A to E) Illustrating the immunohistochemical microscopic finding (400x) for identification of myeloperoxidase (MPO)+ cells (gray color). F) Analytical result of number of positively stained MPO cells, ∗ vs. other groups with different symbols (†, ‡, §), p < 0.0001. G to K) Illustrating the immunofluorescent microscopic finding for identification of CD68+ cells (pink color). L) Analytical result of number of positively stained CD68 cells, ∗ vs. other groups with different symbols (†, ‡, §), p < 0.0001. All scale bars in lower right corner represent 20 μm. All statistical analyses were performed by one-way ANOVA, followed by Bonferroni multiple comparison post hoc test (n = 6). Symbols (∗, †, ‡, §) indicate significance (at 0.05 level). Abbreviations: LV: left ventricular; SC: sham-operated control; IR: ischemia reperfusion; DAPA: dapagliflozin; En: entresto.