Table 3. Association Between the Volume of Regions of Interest (ROIs) and False Recognition Tests^a.

	Mean (SD) change in ROI volume per unit, %	ADAS-Cog 13 false recognition models (n = 725)			RAVLT false recognition models (n = 725)
		OR (95% CI)	P value	Percent change in score per unit	OR (95% CI)	P value	Percent change in score per unit
ROI
Hippocampus
Left	7.4 (1.6)	0.91 (0.88-0.94)	<.001b	9.1	0.96 (0.93-0.99)	.008	4.0
Right	6.6 (3.2)	0.94 (0.92-0.97)	<.001b	6.0	0.98 (0.96-1.01)	.23	NA
Entorhinal cortex
Left	8.1 (1.9)	0.94 (0.91-0.97)	<.001b	6.1	0.97 (0.94-1.00)	.03	3.2
Right	7.8 (1.8)	0.95 (0.92-0.98)	.001	5.2	0.97 (0.94-1.00)	.05	NA
Anterior cingulate gyrus
Left	3.9 (0.6)	0.98 (0.96-1.00)	.03	2.3	0.99 (0.97-1.01)	.14	NA
Right	5.2 (1.0)	0.97 (0.95-1.00)	.01	2.6	0.98 (0.96-1.00)	.08	NA
Superior parietal lobule
Left	1.9 (0.3)	0.99 (0.98-1.00)	.11	NA	1.00 (0.98-1.01)	.33	NA
Right	1.9 (0.3)	0.99 (0.98-1.01)	.27	NA	1.00 (0.99-1.01)	.99	NA
Ventral visual stream
Parahippocampal gyrus
Left	6.0 (1.1)	0.93 (0.91-0.96)	<.001b	6.6	0.96 (0.94-0.99)	.02	3.6
Right	6.1 (1.2)	0.96 (0.94-0.99)	.01	3.7	0.97 (0.94-1.00)	.03	3.1
Fusiform gyrus
Left	2.3 (0.3)	0.97 (0.96-0.99)	<.001b	2.6	0.99 (0.98-1.01)	.36	NA
Right	2.4 (0.4)	0.98 (0.97-1.00)	.01	1.9	0.99 (0.98-1.00)	.10	NA
Lingual gyrus
Left	2.3 (0.3)	0.99 (0.98-1.01)	.31	NA	1.00 (0.99-1.01)	.76	NA
Right	2.2 (0.3)	1.00 (0.98-1.01)	.74	NA	1.00 (0.98-1.01)	.43	NA
Dorsolateral prefrontal cortex
Middle frontal gyrus
Left	1.0 (0.1)	0.99 (0.98-1.00)	.01	0.9	1.00 (0.99-1.00)	.28	NA
Right	1.0 (0.1)	0.99 (0.98-1.00)	.008	0.9	1.00 (0.99-1.00)	.15	NA
Superior frontal gyrus
Left	1.3 (0.1)	0.99 (0.99-1.00)	.20	NA	0.99 (0.98-1.00)	.01	1.2
Right	1.3 (0.1)	0.99 (0.98-1.00)	.02	1.1	0.99 (0.98-1.00)	.07	NA
Ventrolateral prefrontal cortex
Inferior frontal gyrus
Left	5.7 (0.9)	0.96 (0.93-0.99)	.007	4.0	0.98 (0.95-1.00)	.08	NA
Right	5.6 (0.9)	0.98 (0.95-1.01)	.11	NA	0.98 (0.96-1.01)	.23	NA
Inferior frontal orbital gyrus
Left	11.7 (1.8)	0.97 (0.91-1.03)	.29	NA	1.00 (0.94-1.06)	.93	NA
Right	12.1 (1.8)	0.97 (0.91-1.03)	.29	NA	1.01 (0.95-1.07)	.83	NA
Inferior frontal angular gyrus
Left	5.7 (0.9)	0.98 (0.95-1.01)	.12	NA	1.01 (0.98-1.04)	.59	NA
Right	5.6 (0.8)	0.98 (0.95-1.02)	.30	NA	1.00 (0.97-1.03)	.87	NA
Medial prefrontal cortex
Superior medial frontal gyrus
Left	3.0 (0.4)	0.97 (0.96-0.99)	.009	2.7	0.98 (0.96-1.00)	.04	2.0
Right	2.5 (0.4)	0.98 (0.97-1.00)	.02	1.8	0.98 (0.97-1.00)	.02	1.6
Medial frontal cerebrum
Left	11.3 (2.2)	0.95 (0.91-1.00)	.06	NA	0.96 (0.92-1.01)	.12	NA
Right	10.6 (1.9)	0.95 (0.90-0.99)	.02	5.4	0.96 (0.92-1.01)	.11	NA
Orbitofrontal prefrontal cortex
Lateral orbital gyrus
Left	8.2 (1.1)	0.98 (0.93-1.03)	.41	NA	1.00 (0.96-1.05)	.87	NA
Right	7.7 (1.0)	1.00 (0.95-1.05)	.92	NA	0.99 (0.95-1.04)	.66	NA

Abbreviations: ADAS-Cog 13, Alzheimer’s Disease Assessment Scale–Cognitive Subscale, 13 item; NA, not applicable; OR, odds ratio; RAVLT, Rey Auditory Verbal Learning Test.

^a Poisson regression models include the following covariates: age, sex, years of education, Mini-Mental State Examination score, cholinesterase inhibitor prescription, category fluency for animals, and magnetic resonance imaging field strength.

^b Survived Bonferroni correction (P < .001).