Table 1. Frequency of cases by primary clinical diagnosis.

¹ defined as intermediate or high AD neuropathologic change

² includes mild cognitive impairment (MCI), amnestic MCI, and cognitively impaired (not MCI)

³ includes Probable and Possible AD

⁴ includes suspected, possible, probable, and definite ALS

⁵ includes FTLD-bvFTD, FTLD-PPA (sementia dementia), FTLD-PPA (PNFA), FTLD-PPA (logopenic), and FTLD-FTD (NOS)

⁶ includes PD with MCI

⁷ includes PD with dementia, DLB, and DLB with PD

Clinical Diagnosis	n	%	Female	Age at onset mean (y)	Late onset	Age at death mean (y)	Cognitive Impairment or dementia	npAD1	CVD (single)	CVD (multiple)
All	1485	100%	44%	64.9	51%	74.5	66%	48%	32%	16%
Not impaired	129	9%	51%	-	-	73.5	0%	16%	27%	14%
Cognitive impairment2	30	2%	47%	76.5	79%	82.6	100%	80%	37%	27%
AD3	430	29%	54%	68.7	68%	78.2	100%	94%	41%	24%
Vascular dementia	25	2%	48%	75.3	96%	83.4	100%	64%	28%	44%
ALS4	149	10%	39%	59.0	27%	64.0	21%	11%	21%	1%
Frontotemporal disease5	178	12%	45%	61.4	35%	70.5	100%	40%	29%	10%
MSA	42	3%	36%	57.1	18%	66.2	5%	12%	26%	7%
PD6	136	9%	26%	63.6	47%	77.0	35%	18%	32%	13%
PDD/DLB7	185	12%	24%	63.7	44%	76.8	100%	44%	34%	15%
CBS	72	5%	56%	64.7	47%	71.6	26%	46%	35%	21%
PSP	79	5%	38%	66.5	57%	72.7	6%	13%	29%	9%
Schizophrenia	30	2%	73%	-	-	83.1	100%	3%	20%	20%
Logistic regression association with CVD
Predictor	OR	95% CI	p-value
Age at Death	1.20	(1.14, 1.27)	<0.001
Cognitive impairment2	1.77	(0.76, 4.12)	0.18
AD3	2.24	(1.50, 3.36)	<0.001
Vascular dementia	2.54	(0.98, 6.56)	0.06
ALS4	0.54	(0.32, 0.92)	0.02
Frontotemporal disease5	1.00	(0.63, 1.59)	0.99
MSA	0.90	(0.43, 1.89)	0.78
PD6	0.96	(0.59, 1.58)	0.88
PDD/DLB7	1.19	(0.75, 1.86)	0.48
CBS	1.90	(1.05, 3.41)	0.03
PSP	0.88	(0.49, 1.56)	0.65
Schizophrenia	0.65	(0.29, 1.48)	0.31