Table 5. Age and AD associations with CVD .
Age | Neuropathologic AD | ||||||
---|---|---|---|---|---|---|---|
Lesion | Effect | 95% CI | p-value | Effect | 95% CI | p-value | |
Infarct, large | 1.25 | (1.11, 1.41) | <0.001 | 0.98 | (0.60, 1.60) | 0.94 | |
Infarct, lacunar | 1.26 | (1.13, 1.42) | <0.001 | 0.76 | (0.48, 1.20) | 0.24 | |
Infarct, micro | 1.20 | (1.08, 1.33) | <0.001 | 1.28 | (0.85, 1.94) | 0.24 | |
Hemorrhage | 0.94 | (0.80, 1.09) | 0.41 | 1.06 | (0.53, 2.13) | 0.86 | |
Moderate/severe arteriolosclerosis | 1.21 | (1.13, 1.29) | <0.001 | 1.29 | (0.98, 1.72) | 0.07 | |
Moderate/severe CAA | 1.12 | (1.05, 1.19) | <0.001 | 7.42 | (5.61, 9.82) | <0.001 | |
Any single lesion | 1.05 | (0.99, 1.11) | 0.09 | 2.29 | (1.82, 2.89) | <0.001 | |
CVD (multiple) | 1.29 | (1.19, 1.39) | <0.001 | 2.25 | (1.65, 3.06) | <0.001 |