Table 3. Cohort description.
1 all cases with a primary neuropathologic diagnosis of Not AD or low, intermediate or high AD neuropathologic change.
2 all AD spectrum cases excluding atypical presentations such as frontotemporal syndromes.
3 onset of clinical symptoms ≥65 years.
4 moderate to severe atherosclerosis, available for n=1,480.
5 available for n=867.
6 includes aortic stenosis, atrial fibrillation, cardiac arrhythmia, coronary artery disease, and cardiac murmur; available for n=867.
7 available for n=846.
8 includes hyperlipidemia and hypercholesterolemia; available for n=577.
9 includes transient ischemic attack; available for n=845.
10 includes probable AD, possible AD, dementia not otherwise specified, and cognitive impairment.
| Cohort | All | AD spectrum1 | NI to AD2 |
|---|---|---|---|
| n | 1485 | 743 | 566 |
| Age of onset, years (SD) | 64.9 (10.9) | 68.1 (10.3) | 69.1 (10.0) |
| Late onset3 | 51% | 60% | 63% |
| Age at death, years (SD) | 74.5 (11.0) | 77.0 (10.7) | 77.3 (10.8) |
| Female | 44% | 53% | 54% |
| APOE ε4 | 40% | 54% | 55% |
| No impairment | 9% | 18% | 24% |
| Cognitive impairment/dementia | 66% | 78% | 76% |
| Vascular risk factors | |||
| Atherosclerosis4 | 34% | 40% | 39% |
| Diabetes5 | 8% | 10% | 9% |
| Heart6 | 18% | 27% | 28% |
| Hypertension7 | 36% | 43% | 48% |
| Lipid8 | 38% | 42% | 43% |
| Stroke9 | 5% | 10% | 8% |
| Any risk factor | 64% | 73% | 77% |
| Multiple risk factors | 35% | 46% | 50% |
| CVD | |||
| None | 48% | 60% | 61% |
| Single | 32% | 38% | 38% |
| Multiple | 16% | 22% | 23% |
| Neuropathologic AD | |||
| All | 48% | 76% | 78% |
| AD impairment/dementia10 | 28% | 56% | 74% |
| No impairment | 1% | 3% | 4% |
| Atypical | 8% | 17% | 0% |
| Other disease | 10% | 0% | 0% |